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Product details

名称

ICA

分子类型

小分子

英文名称

ICA

货号

I648624-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC 50 of 2.1 µM. In Vitro The SK channel inhibitor ICA exhibits antiarrhythmic effects. ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. ICA at 1 to 10 μM slows conduction velocity. At increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 2.1 µM (Antileishmanial)

生化机理

ICA（N-(吡啶-2-基)-4-(吡啶-2-基)噻唑-2-胺）是一种 SK 通道抑制剂，具有抗利什曼病活性，IC 50 为 2.1 µM。

CAS号

3374-88-7

分子式

C13H10N4S

分子量

254.31 g/mol

PubChem编号

772885

Isomeric SMILES

C1=CC=NC(=C1)C2=CSC(=N2)NC3=CC=CC=N3

IIUPAC Name

N,4-dipyridin-2-yl-1,3-thiazol-2-amine

INCHI

1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17)

InChi Key

RYCUBTFYRLAMFA-UHFFFAOYSA-N

Smiles

C1=CC=NC(=C1)C2=CSC(=N2)NC3=CC=CC=N3

PubChem CID

772885

MeSH Entry Terms

N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine

溶解性

DMSO : ≥ 49.5 mg/mL (194.64 mM)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

254.063 Da

单同位素质量Monoisotopic Mass

254.063 Da

拓扑极表面积Topological Polar Surface Area

78.900 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

263.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

2.700

NSC Number

751858

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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