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Product details

名称

ICAM-1-IN-1

分子类型

小分子

别名

细胞间粘附分子-1-合-1

英文名称

ICAM-1-IN-1

货号

I649334-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin and ICAM-1 with IC 50 values of 7 and 5 nM, respectively. In Vivo ICAM-1-IN-1 shows significant efficacy in a rat rheumatoid arthritis model and in a mouse asthma model. ICAM-1-IN-1 reduces the width of inflamed ankles after the ninth day following treatment, but shows no efficacy in the acute phase. Treatment with ICAM-1-IN-1 (25 mg/kg) for 21 days significantly reduces the ankle inflammation of the arthritis rats. Significant reduction of eosinophils and serum-soluble ICAM-1 (sICAM-1) is observed . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 7 nM (E-selectin), 5 nM (ICAM-1)

生化机理

ICAM-1-IN-1 是一种强效的 E-选择素和 ICAM-1 选择性抑制剂，IC50 值分别为 7 和 5 nM。

CAS号

251994-14-6

分子式

C15H11BrN2O2S

分子量

363.23 g/mol

PubChem编号

10361323

Isomeric SMILES

CNC(=O)C1=CC2=C(S1)C=NC=C2OC3=CC=C(C=C3)Br

IIUPAC Name

4-(4-bromophenoxy)-N-methylthieno[2,3-c]pyridine-2-carboxamide

INCHI

1S/C15H11BrN2O2S/c1-17-15(19)13-6-11-12(7-18-8-14(11)21-13)20-10-4-2-9(16)3-5-10/h2-8H,1H3,(H,17,19)

InChi Key

OFXAEWYLVPBGGU-UHFFFAOYSA-N

Smiles

CNC(=O)C1=CC2=C(S1)C=NC=C2OC3=CC=C(C=C3)Br

PubChem CID

10361323

溶解性

DMSO : ≥ 135 mg/mL (371.67 mM)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

361.972 Da

单同位素质量Monoisotopic Mass

361.972 Da

拓扑极表面积Topological Polar Surface Area

79.500 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

377.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

3.700

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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