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Product introduction

ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 ( SR-B1 ). In Vivo ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1). Treatment of ITX5061 (30 mg/kg/day) for mice results in a 50% increase in HDL-C levels compare to baseline. ApoA-I levels are moderately (+15 %) but significantly increased in ITX5061-treated HuAITg mice, compare to mice receive vehicle. ITX5061 significantly decreases HDL-CE catabolism with an FCR of 1.86±0.40 pools/d vs 2.47±0.26 pools/d in the control group (P Form:Solid IC50& Target:p38 MAPK, SR-B1

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Chinese name

ITX5061

English name

ITX5061

Chinese alias

English alias

UNII-J4RA8K2Q2A | 1252679-52-9 | KC706 | KC-706 | N-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide;hydrochloride | ITX-5061 hydrochloride ; ITX 5061 HCl ; ITX506 HCl pound>>ITX5061 hydroc

CAS number

1252679-52-9

molecular formula

C30H38ClN3O7S

molecular weight

620.16 g/mol

Exact mass

PSA

132.000 Å²

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