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Product introduction

I-138 is an orally active compound structurally related to ML323 . I-138 and ML-323 are potent reversible inhibitors of USP1-UAF1. I-138 displays synergistic binding with ubiquitin and mutual exclusive binding with ML323. I-138 induces the monoubiquitination of FANCD2 and PCNA in MDA-MB-436 cells, increases PCNA and FANCD2 monoubiquitination in HAP-1 USP1 WT cells. I-138 ablates USP1 autocleavage in cells. Form:Solid

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Chinese name

I-138

English name

I-138

Chinese alias

English alias

CAS number

2098211-50-6

molecular formula

C26H23F3N6O

molecular weight

492.50 g/mol

Exact mass

PSA

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