Incyclinide

小分子

环丝氨酸

Incyclinide

I651138-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

Incyclinide (CMT-3, COL-3) is a matrix metalloproteinase ( MMP ) inhibitor, thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. In Vitro Incyclinide has been shown to experimentally suppress prostate cancer, colon adenocarcinoma and melanoma invasiveness in cell culture. Adding incyclinide at final concentrations of 5 to 20 μM inhibits MT1-MMP gelatinolytic and caseinolytic activity, blocks MT1-MMPactivation of pro-MMP-2, and decreases invasiveness of HT-1080 fibrosarcoma cells. Incyclinide is an especially effective inhibitor of the growth and viability of filamentous fungi. Most of the MICs of CMT-3 against filamentous fungi are found to be between 0.25 and 8 μg/mL, and the inhibition of viability of these fungi by incyclinide is routinely higher than 90%. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Incyclinide inhibits tooth movement in the rat, probably by reducing the number of osteoclasts at the compression side. This might be due to induction of apoptosis in activated osteoclasts or reduced osteoclast migration. Reduced MMP activity by incyclinide might also directly inhibit degradation of the organic bone matrix. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Assay Determination of C. albicans growth inhibition by CMT-3 is carried out by a modified turbidity assay. A series of tubes containing PDB (5 mL) and different concentrations of incyclinide (0, 0.125, 0.25, 0.5, 1.0, and 2.0 μg/mL) are each inoculated with a 100 μL suspension of C. albicans in late log phase to yield a final cell concentration of 10 6 /mL. The tubes are aerobically incubated at 35°C, and at each time point (0, 1, 2, 4, 6, 12, and 24 h), the turbidity in each tube is determined spectrophotometrically at 600 nm. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

英西利奈（CMT-3，COL-3）是一种基质金属蛋白酶（MMP）抑制剂，可诱导细胞外基质降解，抑制血管生成、肿瘤生长和侵袭以及转移。

15866-90-7

C19H17NO7

371.34 g/mol

54678924

C1[C@@H]2CC3=C(C(=CC=C3)O)C(=C2C(=O)[C@]4([C@@H]1CC(=O)C(=C4O)C(=O)N)O)O

C1[C@@H]2CC3=C(C(=CC=C3)O)C(=C2C(=O)[C@]4([C@@H]1CC(=O)C(=C4O)C(=O)N)O)O

54678924

DMSO : ≥ 100 mg/mL (269.29 mM)

5

7

1

371.101 Da

371.101 Da

158.000 Ų

27

0

813.000

0

1

1.000