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Product details

名称

IWP-3

英文名称

IWP-3

货号

I654995-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

IWP-3 is an potent inhibitor of Wnt production with an IC 50 of 40 nM. IWP-3 inhibits Porcupine (Porcn) function thereby blocking palmitoylation of Wnt proteins. IWP-3 inhibits CK1γ3 and CK1ε only moderately and does not inhibit CK1α.

生化机理

IWP-3 是一种有效的 Wnt 生成抑制剂，IC50 为 40 nM。IWP-3 可抑制 Porcupine（Porcn）的功能，从而阻断 Wnt 蛋白的棕榈酰化。IWP-3 对 CK1γ3 和 CK1ε 的抑制作用较弱，对 CK1α 没有抑制作用。

CAS号

687561-60-0(DMSO)

分子式

C22H17FN4O2S3

分子量

484.59 g/mol

Smiles

CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=C(C=C5)F)SCC4

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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