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Product details

名称

ICA

分子类型

小分子

英文名称

ICA

货号

I655499-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC 50 of 2.1 µM. In Vitro The SK channel inhibitor ICA exhibits antiarrhythmic effects. ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. ICA at 1 to 10 μM slows conduction velocity. At increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 2.1 µM (Antileishmanial)

生化机理

ICA（N-(吡啶-2-基)-4-(吡啶-2-基)噻唑-2-胺）是一种 SK 通道抑制剂，具有抗利什曼病活性，IC 50 为 2.1 µM。

CAS号

3374-88-7(DMSO)

分子式

C13H10N4S

分子量

254.31 g/mol

Smiles

C1=CC=NC(=C1)C2=CSC(=N2)NC3=CC=CC=N3

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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