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Product details

名称

IDH889

分子类型

小分子

英文名称

IDH889

货号

I656486-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1) . IDH889 has potent selectivity for IDH1 R132* mutations, with IC 50 s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1 R132H , IDH1 R132C and IDH1 wt , respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC 50 of 0.014 μM IC50& Target:IC50: 0.02 μM (IDH1 R132H ), 0.072 μM (IDH1 R132C ), 1.38 μM (IDH1 wt )

生化机理

IDH889 是异柠檬酸脱氢酶 1（IDH1）的一种口服、脑穿透、异位和突变特异性抑制剂。IDH889 对 IDH1 R132* 突变具有强效选择性，对 IDH1 R132H、IDH1 R132H 和 IDH1 R132* 突变的 IC 50 s 分别为 0.02 μM、0.072 μM 和 1.38 μM。

CAS号

1429179-07-6(DMSO)

分子式

C23H25FN6O2

分子量

436.48 g/mol

Smiles

CC1=C(C=CC(=C1)C2=CN=C(N=C2)C(C)NC3=NC=CC(=N3)N4C(COC4=O)C(C)C)F

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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