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Product introduction

伊马替尼是苯甲酰胺，由4-[(4-甲基哌嗪-1-基)甲基]苯甲酸的羧基与4-甲基-N3-[4-(吡啶-3-基)嘧啶-2-基]苯-1,3-二胺的初级芳香族氨基基团缩合而成。(以其甲磺酸盐形式)用于治疗慢性髓性白血病和胃肠间质肿瘤。它具有抗肿瘤剂、酪氨酸激酶抑制剂和凋亡诱导剂的作用。它是苯甲酰胺、吡啶、芳香胺、嘧啶和N-甲基哌嗪的成员。它在功能上与苯甲酰胺相关。

Specs ⸢ View details ⸥

Chinese name

伊马替尼, ABL 原癌基因 1 抑制剂

English name

4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide

Chinese alias

English alias

4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide | CGP-57148 | HMS3244P10 | MFCD05662257 | NCGC00159456-02 | HY-15463 | Imatinibum | NSC743414 | NSC-743414 | CHEBI:45783 | SY028029 | 1iep | Glamox (TN)

CAS number

152459-95-5

molecular formula

C29H31N7O

molecular weight

493.6

Exact mass

PSA

86.3

Logp

3.5

Safety

Harmful effect： * 白细胞减少

Toxicity summary： * 伊马替尼治疗与皮肤毒性相关，包括多形性红斑和史蒂文斯-约翰逊综合征。

Regulatory information： REACH注册物质：状态：活跃更新：2022-05-19 https://echa.europa.eu/registration-dossier/-/registered-dossier/18975

Hepatotoxicity：可能性评分：A(有充分记录的引起明显肝损伤以及乙型肝炎再激活的原因)。

Hazard categories and classifications：乳糖。(72.7%)

Drug Induced Liver Injury：参考文献：DOI:10.1016/j.drudis.2019.09.022

Effects During Pregnancy and Lactation：截至修订日期，未找到相关已发表信息。

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