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Product introduction

Irdabisant (CEP-26401) 是一种具有选择性、口服活性和血脑屏障渗透性的组胺 H3 受体 (histamine H3 receptor, H3R) 拮抗剂/逆激动剂，对大鼠 H3R 和人 H3R 的 Ki 分别为 7.2 nM 和 2.0 nM。Irdabisant 对 hERG 电流的抑制活性相对较低，IC50 为 13.8 μM。Irdabisant 在大鼠社会认知模型中具有认知增强和唤醒作用。 Irdabisant (CEP-26401) is a selective, orally active and blood-brain barrier (BBB) penetrant histamine H3 receptor (H3R) inverse agonist/inverse agonist with Ki values of 7.2 nM and 2.0 nM for rat H3R and human H3R, respectively. Irdabisant has relatively low inhibitory activity against hERG current with an IC50 of 13.8 μM. Irdabisant has cognition-enhancing and wake-promoting activities in the rat social recognition model. Irdabisant can be used to research schizophrenia or cognitive impairment

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Chinese name

Irdabisant, 组胺 H3 受体拮抗剂

English name

Irdabisant

Chinese alias

伊尔达比桑特

English alias

CAS number

1005402-19-6

molecular formula

C18H23N3O2

molecular weight

313.39 g/mol

Exact mass

≥98%

PSA

53.900 Å²

Logp

2.5

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Irdabisant ≥98% 1mg

Name: Irdabisant ≥98% 1mg
Brand: 麦克林
SKU: I981341-1mg

Irdabisant ≥98% 1mg Macklin 1005402-19-6, complete specifications, for production, research, laboratory testing and inspection, digital one-stop procurement platform for scientific materials.

item number：I981341-1mg

Product model：1mg

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Lead Time：30days

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Irdabisant ≥98% 1mg

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