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Product introduction

JTE-607 二盐酸盐是一种前药化合物，可通过酯水解转化为活性形式。JTE-607 是一种多细胞因子产生抑制剂，靶向 CPSF3 并抑制前 mRNA 加工。JTE-607 抑制来自 LPS 刺激的人 PBMC 的肿瘤坏死因子 (TNF)-α、白介素 (IL)-1β、IL-6、IL-8 和 IL-10，IC50 值分别为 11 nM、5.9 nM、8.8 nM、7.3 nM 和 9.1 nM。 Shipped at room temperature. Store at -20°C.

Specs ⸢ View details ⸥

Chinese name

JTE 607二盐酸盐

English name

JTE 607 dihydrochloride

Chinese alias

乙酯-N-[3,5-二氯-2-羟基-4-[2-(4-甲基-1-哌嗪基)乙氧基]苯甲酰基]-L-苯丙氨酸 | 二盐酸盐 | 甲氧番荔枝碱

English alias

2B68H6BWCX | (-)-ethyl-N-[3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl]-L-phenylalaninate dihydrochloride | JTE-607 .2HCl | SCHEMBL5961033 | N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl

CAS number

188791-09-5

molecular formula

C25H31Cl2N3O5•2(HCl)

molecular weight

597.36 g/mol

Exact mass

10mM in DMSO

PSA

91.300 Å²

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