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Product introduction

JZL195是有效的FAAH和MAGL抑制剂，IC50分别为2 nM和4 nM JZL195 has been used: as a selective inhibitor of endocannabinoid (eCB) clearance enzymes to induce in vivo long-term depression at CA3-CA1 synapses and at prelimbic (PrL)-nucleus accumbens (NAc)synapses, to study the neuroprotective action of eCB to inhibit the action of hydrolytic enzymes that limit eCB activity, to study the effect of 2-linoleoylglycerol (2-LG) on the human CB1 receptor activity as a dual fatty acid amide hydrolase (FAAH)/monoacylglycerol lipase (MAGL) inhibitor to study its dose-related antipruritic effect on the serotonin (5-HT)-induced scratching model

Specs ⸢ View details ⸥

Chinese name

JZL195, 酰氧基乙酰水解酶抑制剂

English name

JZL195

Chinese alias

English alias

DTXSID401029877 | FT-0700116 | GTPL8606 | 4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate | AC-36809 | ZINC ACETATE [INCI] | Q6109295 | AKOS024458308 | T0038 | HY-15250 | BCP23894 | SMR004701690 | JZL-195; JZL 195 | NCGC00346837-01 | 4-[(3-Pheno

CAS number

1210004-12-8

molecular formula

C24H23N3O5

molecular weight

433.5 g/mol

Exact mass

PSA

87.800 Å²

Logp

4.300

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