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Product details

名称

JPM-OEt

别名

甲基磷

英文名称

JPM-OEt

货号

J650903-5mg

包装规格

5mg

浓度

≥99%

储存温度

避光,-80℃储存

运输条件

超低温冰袋运输

产品介绍

JPM-OEt is a broad spectrum cysteine cathepsin inhibitor. JPM-OEt binds covalently in the active site, and irreversibly inhibits the cysteine cathepsin family. Antitumor activity. In Vivo JPM-OEt (50 mg/kg; i.p.; daily for 30 days) reduces tumor cathepsin B activity significantly . JPM-OEt (50 mg/kg; i.p.; twice daily for 4 weeks) leads to tumor regression in the RIP1-Tag2 (RT2) mouse model of pancreatic islet cell tumorigenesis. JPM-OEt (50 mg/kg; i.p.; daily from 63 to 98 days) causes a significant delay in the increase of tumour burden during the first 2 weeks of treatment. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female mice of a transgenic mouseDosage: 50 mg/kg Administration: i.p.; daily from 63 to 98 days Result: Caused a significant delay in the increase of tumour burden during the first 2 weeks of treatment. However, on days 84, 91 and 98 no significant differences between both groups could be detected. Form:Solid

生化机理

JPM-OEt 是一种广谱半胱氨酸酪蛋白酶抑制剂。JPM-OEt 与活性位点共价结合，不可逆地抑制半胱氨酸酪蛋白酶家族。抗肿瘤活性。

CAS号

262381-84-0

分子式

C20H28N2O6

分子量

392.45 g/mol

Smiles

O=C([C@H]1O[C@@H]1C(N[C@H](C(NCCC2=CC=C(O)C=C2)=O)CC(C)C)=O)OCC

溶解性

DMSO : 125 mg/mL (318.51 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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