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Product details

名称

JQKD82 trihydrochloride

别名

JQKD82三盐酸盐

英文名称

JQKD82 trihydrochloride

货号

J659315-5mg

包装规格

5mg

浓度

≥99%

储存温度

2-8°C储存,干燥

运输条件

冰袋运输

产品介绍

JQKD82 (JADA82) trihydrochloride is a cell-permeable and selective KDM5 inhibitor. JQKD82 trihydrochloride increases H3K4me3 and can be used for the research of multiple myeloma. Appearance:Solid In Vitro:JQKD82 (0.3 μM; 24 hours) trihydrochloride causes an increase in the global H3K4me3 level of MM.1S cells. JQKD82 (0.1-10 μM; day 1-day 5) trihydrochloride inhibits the growth of MM.1S cells in a dose- and time-dependent manner. JQKD82 trihydrochlorid In Vivo:JQKD82 (50-75mg/kg; i.p.; twice a day for 3 weeks) trihydrochloride has anti-multiple myeloma activity. JQKD82 trihydrochloride displays an increase in H3K4me3 levels and results in a dramatic reduction of MYC immuno-staining in vivo. MCE has n Biological Activity:JQKD82 (JADA82) trihydrochloride is a cell-permeable and selective KDM5 inhibitor. JQKD82 trihydrochloride increases H3K4me3 and can be used for the research of multiple myeloma.

分子式

C27H43Cl3N4O5

分子量

610.01 g/mol

Smiles

O=C(C1=CC(CNCC(N(CCN(C)C)CC)=O)=NC=C1)OC2=CC=C(C=C2OC(C)C)OC(C)C.[H]Cl.[H]Cl.[H]Cl

溶解性

DMSO : 50 mg/mL (81.97 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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