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Product introduction

JNJ-7706621是CDK和Aurora的一个双重抑制剂，在体外可以有效地抑制CDK1、CDK2、CDK3、CDK4、CDK6、Aurora A和Aurora B，对应的IC50值分别为0.009、0.004、0.003、0.058、0.253、0.175、0.011和0.015 μmol/L。JNJ-7706621选择性地抑制正常人细胞和不同类型的肿瘤细胞的增殖，JNJ-7706621对肿瘤细胞(IC50值0.112 - 0.514μmol/L)的作用是正常细胞(IC50值3.67 - 5.42μmol/L)的10倍。在人癌细胞中，不管p53、视网膜母细胞瘤或p-糖蛋白状态如何，JNJ-7706621都可以诱导细胞凋亡、抑制集落形成和细胞生长。

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Chinese name

JNJ-7706621,泛CDK抑制剂, 极光激酶 A 抑制剂极光激酶 B 抑制剂细胞周期蛋白依赖性激酶 1 抑制剂细胞周期蛋白依赖性激酶 2 抑制剂 Janus 激酶 2 抑制剂

English name

JNJ-7706621

Chinese alias

Aurora 激酶 | Cdk 抑制剂

English alias

CAS number

443797-96-4

molecular formula

C15H12F2N6O3S

molecular weight

394.36 g/mol

Exact mass

PSA

154.000 Å²

Logp

2.400

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JNJ-7706621 10mM in DMSO 1ml

Name: JNJ-7706621 10mM in DMSO 1ml
Brand: 麦克林
SKU: J793890-1ml

JNJ-7706621 10mM in DMSO 1ml Macklin 443797-96-4, complete specifications, for production, research, laboratory testing and inspection, digital one-stop procurement platform for scientific materials.

item number：J793890-1ml

Product model：1ml

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Lead Time：30days

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JNJ-7706621 10mM in DMSO 1ml

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