Share to

Overview

Specs

Technical Documents

Articles

reviews

Consult

returns

Product introduction

卡萨霉素B 是瘦链霉菌素复合物的次要成分，该复合物是由a.Streptomyces sp。|的肉汤发酵产生的。该化合物是Leptomycin A的羟基化类似物，它是一种核输出抑制剂，且具有高度亲脂性。| 卡萨霉素B 对肿瘤L1210，P388 / S，B16，HeLa S3，L5178Y-ML或当在卡祖霉素B存在下培养72小时时，确定L929的IC 50为1.8、2.0、0.7、1.8、10.0和1.0ng / ml。该化合物在小鼠中还表现出广泛的抗肿瘤活性，其有效性比体内和体外给药浓度更依赖于给药方案。 Kazusamycin B is a minor component of the leptomycin complex produced from the fermentation of the broth of a|Streptomyces sp.|. The compound is a hydroxylated analogue of Leptomycin A , a nuclear export inhibitor, and highly lipophillic.|In vitro|antitumor activity of Kazusamycin B on tumors L1210, P388/S, B16, HeLa S3, L5178Y-ML or L929 was ascertained to have an IC|50|of 1.8, 2.0, 0.7, 1.8, 10.0 and l.0 ng/ml when cultured in the presence of Kazusamycin B for 72 hours. The compound has also displayed broad antitumor activity in mice with effectiveness being more dependent on dosing regimen than dosing concentration both|in vivo|and|in vitro|. Kazusamycin B also possesses antibacterial and antifungal activity.

Specs ⸢ View details ⸥

Chinese name

卡萨霉素B

English name

Kazusamycin B

Chinese alias

English alias

2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15,17-hexamethyl-8-oxo- | (2E,10E,12E,16Z,18E)-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15,17-hexamethyl-19-(3-methyl-6-oxo-3,6-dihydro-2

CAS number

107140-30-7

molecular formula

C32H46O7

molecular weight

542.7 g/mol

Exact mass

≥95%

PSA

Logp

Technical Documents

「No technical documents」

「No upstream and downstream information yet」

Articles

「No related articles yet」

user reviews

Consultation

Warm reminder：

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.！

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！