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Product introduction

Ko 143是高活性乳腺癌耐药蛋白多药转运通道（BCRP）抑制剂，EC90为26 nM，比对 P-gp和MRP-1转运通道的抑制性高200倍以上。A selective BCRP multidrμg transporter inhibitor Ko 143 is a potent and selective breast cancer resistance protein multidrug transporter (BCRP) inhibitor (EC90 = 26 nM), Ko 143 displays > 200-fold selectivity over P-gp and MRP-1 transporters. A selective BCRP multidrug transporter inhibitor

Specs ⸢ View details ⸥

Chinese name

Ko 143,BCRP抑制剂, ABCG2 抑制剂

English name

Ko 143

Chinese alias

English alias

(3s,6s,12as)-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-(2-methylpropyl) 1,4-dioxopyrazino [1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester | Ko143 | Ko-143 | 3-((3S,6S,12aS)-6-Isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydro

CAS number

461054-93-3

molecular formula

C26H35N3O5·xH2O

molecular weight

469.57 (anhydrous ba

Exact mass

PSA

101.000 Å²

Logp

3.500

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