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名称

KN-93 phosphate

别名

KN-93磷酸盐

英文名称

KN-93 phosphate

货号

K647033-5mg

包装规格

5mg

浓度

≥99%

储存温度

2-8°C储存,干燥

运输条件

冰袋运输

产品介绍

KN-93 phosphate is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II , with K i of 370 nM. In Vitro After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H + , K + -ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca 2+ -independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:CaMK II

生化机理

KN-93 磷酸酯是一种新型的纯化神经元 CaMK-II 膜渗透合成抑制剂，其 K i 为 370 nM。

CAS号

1913269-12-1

分子式

C26H32ClN2O8PS

分子量

599.03 g/mol

PubChem编号

16760530

Isomeric SMILES

CN(C/C=C/C1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC.OP(=O)(O)O

Smiles

CN(C/C=C/C1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC.OP(=O)(O)O

PubChem CID

16760530

溶解性

DMSO : 100 mg/mL (166.94 mM; Need ultrasonic) H2O : 50 mg/mL (83.47 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

598.131 Da

单同位素质量Monoisotopic Mass

598.131 Da

拓扑极表面积Topological Polar Surface Area

156.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

763.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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