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Product details

名称

Kushenol A

分子类型

小分子

别名

苦参酚A

英文别名

MS-27020 | 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(2-hydroxyphenyl)-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (2S)- | CHEBI:197206 | (2S)-2,3-Dihydro-5,7-dihydroxy-2-(2-hydroxyphenyl)-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-y

英文名称

Kushenol A

货号

K649825-5mg

包装规格

5mg

浓度

≥99%

储存温度

避光,-80℃储存

运输条件

超低温冰袋运输

产品介绍

Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent . Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC 50 and K i values of 1.1 μM and 0.4 μM, respectively Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase ( IC 50 : 45 μM; K i : 6.8 μM) and β-amylase . Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging In Vitro Kushenol A (25 μM) exhibits a highly potent inhibitory activity on ABTS+ radical scavenging with an IC 50 value of 9.7 ± 0.1 μM, and exhibits inhibits scavenging activity as a percentage 93.7% at 25 μM. Kushenol A (0-60 μg/ml; 24 hours) shows considerable cytotoxic effects against NSCLC cells, exhibits IC 50 values of 5.3 μg/ml and 20.5 μg/ml for A549 and NCI‐H226 cells, respectively. It shows an IC 50 value of 57.2 μg/ml for BEAS-2B cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: NSCLC cell lines, A549 and NCI-H226 Normal human lung epithelial: BEAS-2B Concentration: 0-60 μg/ml Incubation Time: 24 hours Result: Exhibited considerable cytotoxic effects against NSCLC cells. Form:Solid IC50& Target:IC50: 1.1 μM (tyrosinase),45 μM (alpha-glucosidase)

生化机理

Kushenol A（Leachianone E）是从 Sophora flavescent 的根中分离出来的。Kushenol A 是一种非竞争性酪氨酸酶抑制剂，可阻止 L- 酪氨酸向 L-DOPA 的转化，其 IC 50 和 K i 值分别为 1.1 μM 和 0.4 μM。草酚

CAS号

99217-63-7

分子式

C25H28O5

分子量

408.49 g/mol

PubChem编号

44563121

Isomeric SMILES

CC(=CC[C@H](CC1=C2C(=C(C=C1O)O)C(=O)C[C@H](O2)C3=CC=CC=C3O)C(=C)C)C

IIUPAC Name

(2S)-5,7-dihydroxy-2-(2-hydroxyphenyl)-8-[(2R)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]-2,3-dihydrochromen-4-one

INCHI

1S/C25H28O5/c1-14(2)9-10-16(15(3)4)11-18-20(27)12-21(28)24-22(29)13-23(30-25(18)24)17-7-5-6-8-19(17)26/h5-9,12,16,23,26-28H,3,10-11,13H2,1-2,4H3/t16-,23+/m1/s1

InChi Key

OGBMVWVBHWHRGD-MWTRTKDXSA-N

Smiles

CC(=CCC(CC1=C2C(=C(C=C1O)O)C(=O)CC(O2)C3=CC=CC=C3O)C(=C)C)C

PubChem CID

44563121

关联CAS

99217-63-7

MeSH Entry Terms

kushenol A

溶解性

DMSO : 100 mg/mL (244.80 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

408.194 Da

单同位素质量Monoisotopic Mass

408.194 Da

拓扑极表面积Topological Polar Surface Area

87.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

652.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

6.100

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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