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Product details

名称

11-Ketodihydrotestosterone

别名

11-酮二氢睾酮

英文别名

英文名称

11-Ketodihydrotestosterone

货号

K651369-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

11-Ketodihydrotestosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione. 11-Ketodihydrotestosterone is an active androgen and is also a potent androgen receptor (AR) agonist with a K i of 20.4 nM and an EC 50 of 1.35 nM for human AR . 11-Ketodihydrotestosterone drives gene regulation, protein expression and cell growth in androgen-dependent prostate cancer cells In Vitro 11-Ketodihydrotestosterone (11-KDHT; 1-10 nM; 24 hours; LNCaP and VCaP cells) treatment induces significant cell proliferation. 11-Ketodihydrotestosterone (11-KDHT; 0.1-10 nM; 7-10 days; LNCaP and VCaP cells) treatment results in the significant upregulation of KLK3 , TMPRSS2 and FKBP5 in both LNCaP and VCaP cells, with the exception of KLK3 at 1 nM in LNCaP cells. In PNT2 cells, only 20% of 11β-hydroxyandrostenedione (11OHA4) and 11β-hydroxytestosterone (11OHT) are metabolised with the former yielding 11keto-androstenedione (11KA4), 11-Ketodihydrotestosterone (11-KDHT) and 11β-hydroxy-5α-androstanedione (11OH-5αDIONE) and the latter yielding 11OHA4, 11KT and 11-Ketodihydrotestosterone with downstream products Form:Solid IC50& Target:Ki: 20.4 nM (Human androgen receptor), EC50: 1.35 nM (Human androgen receptor)

生化机理

11-Ketodihydrotestosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) 是一种内源性类固醇，是 11β-Hydroxyandrostenedione 的代谢产物。11-Ketodihydrotestosterone 是一种活性雄激素，也是一种强效的雄激素受体（AR）激动剂，其 K i

CAS号

32694-37-4

分子式

C19H28O3

分子量

304.42 g/mol

PubChem编号

11197479

Isomeric SMILES

C[C@]12CCC(=O)C[C@@H]1CC[C@@H]3[C@@H]2C(=O)C[C@]4([C@H]3CC[C@@H]4O)C

IIUPAC Name

(5S,8S,9S,10S,13S,14S,17S)-17-hydroxy-10,13-dimethyl-2,4,5,6,7,8,9,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,11-dione

INCHI

1S/C19H28O3/c1-18-8-7-12(20)9-11(18)3-4-13-14-5-6-16(22)19(14,2)10-15(21)17(13)18/h11,13-14,16-17,22H,3-10H2,1-2H3/t11-,13-,14-,16-,17+,18-,19-/m0/s1

InChi Key

RSQKILYTRHKUIJ-HZGXJFKTSA-N

Smiles

CC12CCC(=O)CC1CCC3C2C(=O)CC4(C3CCC4O)C

PubChem CID

11197479

关联CAS

32694-37-4

MeSH Entry Terms

11-ketodihydrotestosterone

溶解性

DMSO : 100 mg/mL (328.49 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

304.204 Da

单同位素质量Monoisotopic Mass

304.204 Da

拓扑极表面积Topological Polar Surface Area

54.400 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

527.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

2.300

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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