KN-93 phosphate

KN-93磷酸盐

KN-93 phosphate

K654838-1ml

1ml

10mM in DMSO

干燥,-80℃储存

超低温冰袋运输

KN-93 phosphate is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II , with K i of 370 nM. In Vitro After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H + , K + -ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca 2+ -independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:CaMK II

KN-93 磷酸酯是一种新型的纯化神经元 CaMK-II 膜渗透合成抑制剂，其 K i 为 370 nM。

1913269-12-1(DMSO)

C26H32ClN2O8PS

599.03 g/mol

OP(O)(O)=O.O=S(C1=CC=C(OC)C=C1)(N(C2=CC=CC=C2CN(C/C=C/C3=CC=C(Cl)C=C3)C)CCO)=O