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名称

K-Ras G12C-IN-4

英文名称

K-Ras G12C-IN-4

货号

K656337-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRAS G12C. In Vitro K-Ras G12C-IN-4 (4 hours) exhibits IC 50 =0.219 μM for inhibition of MAPK signaling (p-ERK) in MIA PaCa-2 cells. K-Ras G12C-IN-4 (72 hours) translates to a 0.067 μM IC 50 for inhibition of cellular viability in a CellTiter-Glo experiment in MIA PaCa-2 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

生化机理

K-Ras G12C-IN-4（化合物 1）是一种强效的 KRAS G12C 共价抑制剂。

CAS号

2376328-55-9(DMSO)

分子式

C31H33ClN4O4

分子量

561.07 g/mol

Smiles

O=C(NC1CN(C(C=C)=O)C1)CN2C(C3CC3)=C(C(N4CC5=C(C(OC)=CC=C5)CC4)=O)C6=C2C(C)=CC(Cl)=C6

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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