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名称

拉曲吡啶二盐酸盐

分子类型

小分子

别名

2,3,4,5-四氢-2,8-二甲基-5-[2-(6-甲基-3-吡啶基)乙基]-1H-吡啶并[4,3-B]吲哚二盐酸盐

英文别名

A915372 | 2,3,4,5-tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole 2HCl | 2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole;dihydrochloride | AS-59712 | GTWLIQOLGOZTLF-UHFFFAOYSA-N | Q27270139

英文名称

Latrepirdine dihydrochloride

货号

L129669-10mg

包装规格

10mg

浓度

≥96%

储存温度

-20°C储存

运输条件

超低温冰袋运输

敏感性

对湿度敏感

产品介绍

Latrepirdine dihydrochloride 是一种神经活性化合物，对组胺受体 (histaminergic receptor)，α-肾上腺素能受体 (α-adrenergic receptor) 和 5-羟色胺受体 (serotonergic receptor) 具有拮抗活性。Latrepirdine 刺激淀粉样前体蛋白 (APP) 分解代谢和 β-淀粉样蛋白 (amyloid-β, Aβ) 分泌。

生化机理

AMPK的激活剂，AMPA的xa0增强剂，以及L型电压依赖性Ca2 +通道，NMDA受体，H1 / 2组胺受体，α-肾上腺素受体和5-HT2C / 5A / 6受体的抑制剂。在神经中显示神经保护和认知增强作用 Mechanism of neuroprotection and cognition enhancement is not certain, but Dimebon blocks both cholinesterase and the NMDA receptor simultaneously and also appears to block the action of neurotoxic β-amyloid proteins and inhibit L-type calcium channels, and may exert a neuroprotective effect by blocking a novel target that involves mitochondrial pores.

CAS号

97657-92-6

分子式

C21H25N3·2HCl

分子量

392.37 g/mol

EC号

PubChem SID: 504769722

PubChem编号

23729232

Isomeric SMILES

CC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)CCC4=CN=C(C=C4)C.Cl.Cl

IIUPAC Name

2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole;dihydrochloride

INCHI

1S/C21H25N3.2ClH/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17;;/h4-7,12-13H,8-11,14H2,1-3H3;2*1H

InChi Key

GTWLIQOLGOZTLF-UHFFFAOYSA-N

Smiles

CC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)CCC4=CN=C(C=C4)C.Cl.Cl

PubChem CID

23729232

PubChem SID

504769722

溶解性

DMSO 24 mg/mL Water 79 mg/mL Ethanol 13 mg/mL

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

391.158 Da

单同位素质量Monoisotopic Mass

391.158 Da

拓扑极表面积Topological Polar Surface Area

21.100 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

425.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

备注

有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

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