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名称

TGF-beta/Smad 信号通路

分子类型

小分子

英文别名

L-threo-Dihydrosphingosine | SMP2_000060 | 1, 2-amino- (2S,3S) | 2S,3S-Dihydrosphingosine | SAFINGOL [USAN] | SPC-100270 | Tox21_111227 | 2S-aminooctadecane-1,3R-diol | OWA98U788S | SL-205 | DB11924 | NCGC00093867-01 | Tox21_111227_1 | Bio1_000520 | rel-(

英文名称

L-threo-dihydrosphingosine (d18:0)

货号

L130602-10mg

包装规格

10mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

PKC和鞘氨醇激酶抑制剂 A dual inhibitor of PKC and SPHK Application: L-threo-Dihydrosphingosine is a lyso-sphingolipid protein kinase C inhibitor. It suppresses the growth of human oral squamous cell carcinoma (SCC)

生化机理

具有细胞渗透性的可逆溶血鞘糖脂蛋白激酶C（PKC）抑制剂（IC 50 = 40 µM）。抗癌剂。增强D oxorubicin（DOX）在荷瘤动物中的作用以及丝裂霉素C在癌细胞中的细胞毒性。

CAS号

15639-50-6

分子式

C18H39NO2

分子量

301.51 g/mol

MDL号

MFCD00792847

PubChem编号

3058739

Isomeric SMILES

CCCCCCCCCCCCCCC[C@@H]([C@H](CO)N)O

IIUPAC Name

(2S,3S)-2-aminooctadecane-1,3-diol

INCHI

1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18-/m0/s1

InChi Key

OTKJDMGTUTTYMP-ROUUACIJSA-N

Smiles

CCCCCCCCCCCCCCCC(C(CO)N)O

溶解性

Soluble in chloroform, water (partly miscible), DMSO (~2 mg/ml), DMF (~10 mg/ml), ethanol, and methanol.

熔点

106.8-108.7° C

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

301.298 Da

单同位素质量Monoisotopic Mass

301.298 Da

拓扑极表面积Topological Polar Surface Area

66.500 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

200.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

5.800

闪点(℃)

>110 °C

沸点

>300° C

Reaxy-Rn

1772584

备注

如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

L-苏-二氢鞘氨醇(d18

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

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