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Product introduction

Lestaurtinib 是一种口服有效的选择性受体酪氨酸激酶抑制剂，能竞争性地抑制 ATP 与 TrkA/B/C 激酶结合。Lestaurtinib 可抑制 RPTKs 的磷酸化，其对 FLT3、TrkA、JAK2 的 IC50 值分别为 2, 25 和 0.9 nM。Lestaurtinib 能诱导细胞凋亡和周期停滞，可显著抑制肿瘤的生长。 Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Specs ⸢ View details ⸥

Chinese name

来他替尼, 酪氨酸蛋白激酶受体 RET 抑制剂

English name

Lestaurtinib

Chinese alias

English alias

SPM-924 | (5S,6S,8R)-6-hydroxy-6-(hydroxymethyl)-5-methyl-7,8,14,15-tetrahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacen-13(6H)-one | CEP-701 | KT-5555

CAS number

111358-88-4

molecular formula

C26H21N3O4

molecular weight

439.46 g/mol

Exact mass

PSA

88.700 Å²

Logp

2.2

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