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Product introduction
根据世界卫生组织国际癌症研究机构(IARC)的说法,炔诺醇可致癌。
Chinese name
利奈孕醇
English name
(8R,9S,10R,13S,14S,17R)-17-ethynyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol
Chinese alias
-
English alias
19-Nor-17-alpha-pregn-4-en-20-yn-17-l
CAS number
52-76-6
molecular formula
C20H28O
molecular weight
284.4
Exact mass
-
PSA
20.2
Logp
4.5
Safety
  • Disposal method: SRP:在审查时,小量处置的监管标准正在重大修订中,但家庭废药品可按以下方式管理:与湿猫砂或咖啡渣混合,用塑料袋双层包装,丢弃在垃圾中。
  • Regulatory information: 加州化妆品安全计划(CSCP)报告成分:报告 - 无论成分在产品中的预期功能如何
  • interaction: 提前48小时给予炔诺酮可加速苯巴比妥和苯妥英从小鼠血浆中的清除,从而减弱它们的抗惊厥作用。同样的预处理可缩短己巴比妥的睡眠时间并加速其体外代谢。苯巴比妥和苯妥英清除率的增加可能是由于炔诺酮加速了它们的代谢。
  • Other safety information: 化学评估:IMAP评估 - 19-去孕-4-烯-20-炔-17-醇, (17.alpha.)-: 人类健康I级评估
  • Hazard categories and classifications: STOT RE 1 (89.5%)
  • Non-human toxic extract: /遗传毒性/ 合成孕激素炔诺孕酮的遗传毒性研究在骨髓细胞中进行,使用姐妹染色单体交换(SCEs)和染色体畸变(CAs)作为参数。炔诺孕酮在三个不同剂量(6.87、13.75和27.50 mg/kg体重)下进行研究。与正常对照组相比,用13.75和27.50 mg/kg体重剂量的炔诺孕酮处理后,SCE和CA显著增加。目前的研究结果表明,炔诺孕酮在小鼠骨髓细胞中具有遗传毒性和细胞毒性。
  • Antidote and first aid: /SRP:/ 高级治疗:对于意识不清、严重肺水肿或严重呼吸窘迫的患者,考虑经口或经鼻气管插管进行气道控制。使用气囊面罩装置进行正压通气技术可能有益。考虑对肺水肿进行药物治疗...。对于严重支气管痉挛,考虑给予β激动剂如沙丁胺醇...。监测心律并根据需要治疗心律失常...。开始静脉注射D5W /SRP: "保持通畅",最小流速/。如果出现低血容量迹象,使用0.9%生理盐水(NS)或乳酸盐林格氏液。对于伴有低血容量体征的低血压,谨慎给予液体。注意液体过载的迹象...。用地西泮或劳拉西泮治疗癫痫...。使用...
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upstream information
Manufacturing method:
19-去甲睾酮(CID:44352419); 乙烷-1,2-二硫醇(CID:87812323); 三氟化硼(CID:6356); 氨(CID:222); 铬酸(CID:24425); 雌-4-烯-17-酮(CID:107437); 炔诺醇(CID:5857)
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Research chemical 1ml

Research chemical 1ml; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 1ml.

item number:L424528-1ml
Product model:1ml
level: 1ml
Lead Time:-
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