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名称

LIT-001

英文名称

LIT-001

货号

L646912-5mg

包装规格

5mg

浓度

≥98%

储存温度

2-8°C储存,干燥

运输条件

冰袋运输

产品介绍

LIT-001 is the first nonpeptide oxytocin receptor (OT-R) agonist ( EC 50 =55 nM; K i =226 nM). LIT-001 improves social interaction in a mouse model of autism In Vitro In vitro signaling experiments, LIT-001 is a nonbiased OT-R agonist on the two main signaling pathways of this receptor, with minor antagonist effect on V1a and agonist effect on V1b receptors, observed at high concentrations only. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD ) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Oprm1 –/– mice (bred in house on a 50% 129SVPas–50% C57BL/6J hybrid background) Dosage: 10, 20 mg/kg Administration: i.p. Result: Alleviated core symptoms in the context of ASD. Form:Solid IC50& Target:EC50: 55 nM (OT-R), Ki: 226 nM (OT-R)

生化机理

LIT-001 是首个非肽催产素受体（OT-R）激动剂（EC 50 =55 nM；K i =226 nM）。LIT-001 可改善自闭症小鼠模型的社会互动。

CAS号

2245072-21-1

分子式

C30H34F3N7O4S

分子量

645.7 g/mol

PubChem编号

145711713

IIUPAC Name

(2S)-2-(dimethylcarbamothioyl)-N-[[2-methyl-4-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepine-5-carbonyl)phenyl]methyl]pyrrolidine-1-carboxamide;2,2,2-trifluoroacetic acid

INCHI

1S/C28H33N7O2S.C2HF3O2/c1-18-14-19(11-12-20(18)15-29-28(37)34-13-7-10-24(34)27(38)32(2)3)26(36)35-17-21-16-30-33(4)25(21)31-22-8-5-6-9-23(22)35;3-2(4,5)1(6)7/h5-6,8-9,11-12,14,16,24,31H,7,10,13,15,17H2,1-4H3,(H,29,37);(H,6,7)/t24-;/m0./s1

InChi Key

BZHSRXWFCSEPQQ-JIDHJSLPSA-N

Smiles

CC1=C(C=CC(=C1)C(=O)N2CC3=C(NC4=CC=CC=C42)N(N=C3)C)CNC(=O)N5CCCC5C(=S)N(C)C.C(=O)(C(F)(F)F)O

PubChem CID

145711713

MeSH Entry Terms

(S)-2-(Dimethylcarbamothioyl)-N-(2-methyl-4-(1-methyl-1,4,5,10-tetrahydrobenzo(b)pyrazolo(3,4-e)(1,4)diazepine-5-carbonyl)benzyl)pyrrolidine-1-carboxamide 2,2,2-trifluoroacetate;LIT-001

溶解性

DMSO : 100 mg/mL (154.87 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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