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名称

Lipofermata

分子类型

小分子

别名

脂强化菌

英文名称

Lipofermata

货号

L647455-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

Lipofermata is a fatty acid transport protein 2 (FATP2) inhibitor. Lipofermata shows fatty acid transport inhibition with an IC 50 of 4.84 μM in Caco-2 cells. Lipofermata, an analog of spiro-indoline-thadiazole, shows zinc-specific suppression of antibacterial activity. Lipofermata perturbs zinc homeostasis in E. coli K-12 with a MIC of 16 μM . In Vitro Lipofermata inhibits C1-BODIPY-C12 transport into C2C12, INS-1E, Caco-2 and HepG2 cells at comparable levels yielding sigmoidal dose-response curves with IC 50 s in the low micromolar range (IC 50 =2.74-39.34 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

生化机理

Lipofermata 是一种脂肪酸转运蛋白 2（FATP2）抑制剂。Lipofermata 可抑制脂肪酸转运，在 Caco-2 细胞中的 IC 50 为 4.84 μM。Lipofermata 是螺吲哚啉-噻二唑的类似物，具有锌特异性抗菌抑制作用。

CAS号

297180-15-5

分子式

C15H10BrN3OS

分子量

360.2 g/mol

PubChem编号

3136622

Isomeric SMILES

C1=CC=C(C=C1)C2=NNC3(S2)C4=C(C=CC(=C4)Br)NC3=O

IIUPAC Name

5-bromo-5'-phenylspiro[1H-indole-3,2'-3H-1,3,4-thiadiazole]-2-one

INCHI

1S/C15H10BrN3OS/c16-10-6-7-12-11(8-10)15(14(20)17-12)19-18-13(21-15)9-4-2-1-3-5-9/h1-8,19H,(H,17,20)

InChi Key

RRBYYBWDUNSVAW-UHFFFAOYSA-N

Smiles

C1=CC=C(C=C1)C2=NNC3(S2)C4=C(C=CC(=C4)Br)NC3=O

PubChem CID

3136622

溶解性

DMSO : 100 mg/mL (277.60 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

358.973 Da

单同位素质量Monoisotopic Mass

358.973 Da

拓扑极表面积Topological Polar Surface Area

78.800 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

480

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

3.8

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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