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Product introduction

LDN-211904 oxalate (compound 32) 是一种有效的选择性 EphB3 抑制剂，IC50 为 0.079 µM。LDN-211904 oxalate 在小鼠肝微粒体中表现出良好的代谢稳定性。LDN-211904 oxalate 与西妥昔单抗联用可有效抑制 STAT3 激活的 CSC 干性和 CRC 中的西妥昔单抗耐药性。 LDN-211904 oxalate (compound 32) is a potent and selective EphB3 inhibitor with an IC50 of 0.079 µM. LDN-211904 oxalate shows good metabolic stability in mouse liver microsomes. LDN-211904 oxalate with cetuximab could be effective in inhibiting STAT3-activated CSC stemness and cetuximab resistance in CRC.

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Chinese name

LDN-211904 oxalate

English name

LDN-211904 oxalate

Chinese alias

LDN-211904 草酸盐

English alias

N-(2-chlorophenyl)-6-(piperidin-4-yl)imidazo[1,2-a]pyridine-3-carboxamide oxalate, EphB3 inhibitor

CAS number

1198408-78-4

molecular formula

C21H21ClN4O5

molecular weight

444.87 g/mol

Exact mass

≥95%

PSA

133.000 Å²

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