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Product introduction

LY900009 is a potent and orally active, First-in-class inhibitor of Notch signaling via selective inhibition of the γ-secretase protein (GSI). LY900009 inhibited Notch signalling in tumor cell lines and endothelial cells (IC 50 range: 0.005-20 nM). LY900009 can be used for advanced cancer research. In Vivo LY900009 (oral gavage; 3 mg/kg; single dosage) revealed inhibition of angiogenesis through formation of leaky vasculature and produced tumour regression in Notch-dependent tumour models in a rat model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

Specs ⸢ View details ⸥

Chinese name

LY900009

English name

LY900009

Chinese alias

English alias

(2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]amino]-1-oxopropan-2-yl]butanamide | LY900009 | LY-900009 | (2S)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-2-hydr

CAS number

209984-68-9

molecular formula

C23H27N3O4

molecular weight

409.48 g/mol

Exact mass

≥98%

PSA

98.700 Å²

Logp

2.500

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