LY 3000328

小分子

(3R,4S)-4-(4-Fluorobenzamido)-6-[4-(oxetan-3-yl)piperazin-1-yl]-3,4-dihydro-2H-1-benzopyran-3-yl methylcarbamate | AKOS030526459 | LY3000328 | LY-3000328 | Cathepsin S inhibitorCathepsin S inhibitor | Z-FL-COCHO | C72497 | EX-A2231 | SCHEMBL2618738 | (3R,

LY 3000328

L649222-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

LY 3000328 (Z-FL-COCHO) is a potent and selective Cathepsin S (Cat S) inhibitor with IC 50 s of 7.7 and 1.67 nM for hCat S and mCat S, respectively. In Vitro LY 3000328 maintains excellent in vitro potency and selectivity. LY 3000328 shows low in vitro CYP450 inhibition ( 4%). At a 100 μM concentration of LY 3000328 there is only 6% displacement of [ 3 H]-astemizole in an assay with HEK293 membrane preparation, indicating low potential of hERG blockade. LY 3000328 is a potent and specific inhibitor of cathepsin S (CatS). Inhibition of CatS activity in plasma would be 50% of maximal when LY 3000328 plasma concentration is approximately 60 ng/mL. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo The efficacies of LY 3000328 is studied in a mouse model of abdominal aortic aneurysm (AAA). In this model, inflammation is induced using CaCl 2 applied to the ablumenal surface. It is shown that features of the disease state in this model resemble those of human AAA. LY 3000328 exhibits a dose-responsive aortic diameter reduction at 1, 3, 10, and 30 mg/kg. At the lowest dose of 1 mg/kg of LY 3000328, the aortic diameter is reduced by 58%, then 83% at 3 mg/kg, and 87% at 10 mg/kg. The exposure (AUC) for both compounds increased in a dose-dependent manner, suggesting that the drug disposition properties of LY 3000328 are favorable . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:cathepsin S

LY 3000328（Z-FL-COCHO）是一种强效的选择性胰蛋白酶 S（Cat S）抑制剂，对 hCat S 和 mCat S 的 IC 50 s 分别为 7.7 和 1.67 nM。

1373215-15-6

C25H29FN4O5

484.5 g/mol

67475270

CNC(=O)O[C@H]1COC2=C([C@@H]1NC(=O)C3=CC=C(C=C3)F)C=C(C=C2)N4CCN(CC4)C5COC5

[(3R,4S)-4-[(4-fluorobenzoyl)amino]-6-[4-(oxetan-3-yl)piperazin-1-yl]-3,4-dihydro-2H-chromen-3-yl] N-methylcarbamate

1S/C25H29FN4O5/c1-27-25(32)35-22-15-34-21-7-6-18(29-8-10-30(11-9-29)19-13-33-14-19)12-20(21)23(22)28-24(31)16-2-4-17(26)5-3-16/h2-7,12,19,22-23H,8-11,13-15H2,1H3,(H,27,32)(H,28,31)/t22-,23-/m0/s1

NDEBZCZEAVMSQF-GOTSBHOMSA-N

CNC(=O)OC1COC2=C(C1NC(=O)C3=CC=C(C=C3)F)C=C(C=C2)N4CCN(CC4)C5COC5

67475270

1373215-15-6

LY3000328

DMSO : ≥ 50 mg/mL (103.19 mM)

2

8

6

484.212 Da

484.212 Da

92.400 Ų

35

0

739

0

1

2