LPA2 antagonist 2

小分子

LPA2 拮抗剂 2

4,4'-(4,4'-Biphenyldiyldiimino)bis(4-oxo-2-butenoic acid) | E,E-3-[4'-(3-Carboxy-acryloylamino)-biphenyl-4-ylcarbamoyl]-acrylic acid

LPA2 antagonist 2

L650214-5mg

5mg

≥95%

-20°C储存

超低温冰袋运输

LPA2 antagonist 2 (H2L 5226501) is a selective LPA 2 antagonist with an IC 50 of 28.3 nM and a K i of 21.1 nM. LPA2 antagonist 2 is >480-fold more selective than LPA 3 ( IC 50 of 13.85 μM) In Vitro Lysophosphatidic acid (LPA) is a phospholipid mediator that elicits a host of biological effects including cell proliferation, survival, motility and differentiation. LPA has been shown to regulate cancer cell invasion, metastasis, and resistance to both chemotherapeutics and radiation. LPA2 antagonist 2 (H2L 5226501) inhibits LPA 1 with an Imax of 59.0% at 30 µM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 28.3 nM (LPA 2 ),13.85 μM (LPA 3 )

LPA2 拮抗剂 2（H2L 5226501）是一种选择性 LPA2 拮抗剂，其 IC 50 为 28.3 nM，K i 为 21.1 nM。LPA2 拮抗剂 2 的选择性比 LPA 3 高出 480 多倍（IC 50 为 13.85 μM）。

36840-10-5

C20H16N2O6

380.35 g/mol

O=C(O)/C=C/C(NC1=CC=C(C2=CC=C(NC(/C=C/C(O)=O)=O)C=C2)C=C1)=O

DMSO : 83.33 mg/mL (219.09 mM; Need ultrasonic)