Share to

Details

Safety

Technical Documents

Articles

reviews

Consult

returns

Product details

名称

Lotilaner

分子类型

小分子

别名

洛蒂拉纳

英文名称

Lotilaner

货号

L651016-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

Lotilaner is a parasiticide , acts as a potent non-competitive antagonist of insects GABACl receptors , with an IC 50 of 23.84 nM for Drosophila melanogaster GABA receptor . No effect on a dog GABAA receptor In Vitro Lotilaner shows IC 50 s of 38.25 ± 3.75, 52.40 ± 4.54, 36.79 ± 4.39 nM for Drosophila melanogaster dieldrin/fipronil-resistant forms (DmR2), Lepeophtheirus salmonis (Ls) and Rhipicephalus microplus (Rm) GABACl receptors, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 23.84 nM (DmS-GABA), 38.25 nM (DmR2-GABA), 52.40 nM (Ls-GABA1), 36.79 nM (Rm-GABA)

生化机理

Lotilaner 是一种杀寄生虫药，是昆虫 GABACl 受体的强效非竞争性拮抗剂，对黑腹果蝇 GABA 受体的 IC 50 为 23.84 nM。对狗的 GABAA 受体无影响。

CAS号

1369852-71-0

分子式

C20H14Cl3F6N3O3S

分子量

596.76 g/mol

PubChem编号

76959255

Isomeric SMILES

CC1=C(SC(=C1)C2=NO[C@@](C2)(C3=CC(=C(C(=C3)Cl)Cl)Cl)C(F)(F)F)C(=O)NCC(=O)NCC(F)(F)F

Smiles

CC1=C(SC(=C1)C2=NO[C@@](C2)(C3=CC(=C(C(=C3)Cl)Cl)Cl)C(F)(F)F)C(=O)NCC(=O)NCC(F)(F)F

PubChem CID

76959255

溶解性

DMSO : ≥ 100 mg/mL (167.57 mM)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

594.973 Da

单同位素质量Monoisotopic Mass

594.973 Da

拓扑极表面积Topological Polar Surface Area

108.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

868.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

6.600

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

Consultation

Warm reminder：

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.！

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！