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Product details

名称

LAS101057, 腺苷 A2b 受体拮抗剂

分子类型

小分子

英文别名

英文名称

LAS101057

货号

L651088-5mg

包装规格

5mg

浓度

≥99%

储存温度

避光,-80℃储存

运输条件

超低温冰袋运输

产品介绍

LAS101057 is a potent, selective, and orally efficacious A2B receptor antagonist. In Vivo At 3 mg/kg, LAS101057 is active in preventing Acetyl-β-methylcholine-induced AHR, and at 10 mg/kg it inhibits AHR to Acetyl-β-methylcholine to a level virtually equal to that seen with Hexadecadrol at 1 mg/kg . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

生化机理

LAS101057 是一种强效、选择性和口服有效的 A2B 受体拮抗剂。

CAS号

925676-48-8

分子式

C18H14FN5O

分子量

335.34 g/mol

PubChem编号

16071896

Isomeric SMILES

C1CC1C(=O)NC2=CN=C(C(=N2)C3=CN=CC=C3)C4=C(C=NC=C4)F

IIUPAC Name

N-[5-(3-fluoropyridin-4-yl)-6-pyridin-3-ylpyrazin-2-yl]cyclopropanecarboxamide

INCHI

1S/C18H14FN5O/c19-14-9-21-7-5-13(14)17-16(12-2-1-6-20-8-12)23-15(10-22-17)24-18(25)11-3-4-11/h1-2,5-11H,3-4H2,(H,23,24,25)

InChi Key

XUYURJQIMYCWBB-UHFFFAOYSA-N

Smiles

C1CC1C(=O)NC2=CN=C(C(=N2)C3=CN=CC=C3)C4=C(C=NC=C4)F

PubChem CID

16071896

溶解性

DMSO : ≥ 125 mg/mL (372.76 mM)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

335.118 Da

单同位素质量Monoisotopic Mass

335.118 Da

拓扑极表面积Topological Polar Surface Area

80.700 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

474

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

ALogP

作用类型

拮抗剂

作用机制

腺苷 A2b 受体拮抗剂

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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