L82

L82

L655423-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

L82 is a selective and uncompetitive DNA ligase 1 ( DNA Lig1 ) inhibitor (hLig1 IC 50 =12 μM). L82 shows anti-proliferative activity to breast cancer cells. In Vitro L82 (0-50 μM; 6 d) shows anti-proliferative activity to breast cancer cells. L82 (50 μM; 0-48 h) shows cytostatic activity due to activation of the G1/S checkpoint in MCF7 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: MCF10A, MCF7, HCT116, and HeLa cells Concentration: 0-50 μM Incubation Time: 6 days Result: Reduced the proliferation of a normal breast epithelial cell line MCF10A and the breast cancer cell lines MCF7, HeLa and HCT116, in a concentration-dependent manner. Cell Cycle AnalysisCell Line: MCF7 cells Concentration: 50 μM Incubation Time: 0-48 hours Result: Showed a transient accumulation of cells at G2/M after 12 h, then showed an accumulation at G0/G1 that peaked after 24 h. Decreased in the S phase cell in accompany with the increase in the G0/G1 phase.

L82 是一种选择性和非竞争性 DNA 连接酶 1（DNA Lig1）抑制剂（hLig1 IC 50 =12 μM）。L82 对乳腺癌细胞具有抗增殖活性。

329227-30-7(DMSO)

C11H8ClN5O4

309.67 g/mol

O=C1NN=CC(N/N=C/C2=CC=C(C([N+]([O-])=O)=C2)O)=C1Cl