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Product details

名称

LCAHA

英文名称

LCAHA

货号

L656082-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC 50 s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a. In Vitro LCAHA inhibits HCT116 wt and HCT116 p53 -/- colon cancer cells viability with GI 50 s of 0.87±0.09 and 0.96±0.29μM, respectively, and the LD 50 s of 27.8±3.9 and 26.5±0.1μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HCT116 wt and HCT116 p53 -/- colon cancer cells Concentration: 0.01, 0.1, 1, 10, and 100 μM Incubation Time: 6 days Result: The GI 50 s are 0.87±0.09 and 0.96±0.29 μM for HCT116 wt and HCT116 p53 -/- colon cancer cells, respectively.

生化机理

LCAHA （LCA hydroxyamide）是一种去泛素化酶 USP2a 抑制剂，在 Ub-AMC 分析和 Di-Ub 分析中的 IC 50 s 分别为 9.7 μM 和 3.7μM。LCAHA 通过抑制去泛素化酶 USP2a 来破坏 Cyclin D1 的稳定性并诱导 G0/G1 停滞。

CAS号

117094-40-3(DMSO)

分子式

C24H41NO3

分子量

391.59 g/mol

Smiles

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(NO)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])CC3)C

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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