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名称

Lys-[Des-Arg9]Bradykinin TFA

别名

Lys-[Des-Arg9]缓激肽 TFA

英文名称

Lys-[Des-Arg9]Bradykinin TFA

货号

L656145-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

避光,干燥,-80℃储存

运输条件

超低温冰袋运输

产品介绍

Lys-[Des-Arg9]Bradykinin TFA, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a K i of 0.12 nM, 1.7 nM and 0.23 nM for human , mouse and rabbit B1 receptors , respectively. Lys-[Des-Arg9]Bradykinin TFA has low inhibitory activity on B2 receptors In Vitro Lys-[Des-Arg9]Bradykinin is formed by the proteolytic cleavage of bradykinin, exerts its effects through bradykinin B1 receptor (B1R). Lys-[Des-Arg9]Bradykinin (Lda-BK; 10 μM) enhances the secretion of IL-12p70 and inhibits the secretion of IL-12p40 by mature hMo-DCs. Pretreatment with Lys-[Des-Arg9]Bradykinin treatment reduces the migration of mature hMo-DCs toward medium alone, suggesting that Lys-[Des-Arg9]Bradykinin may inhibit the chemokinesis of mature hMo-DCs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Lys-[Des-Arg9]Bradykinin (1 μg; intra-artenal injection; New Zealand White rabbits) treatment reduces peripheral vascular resistance in LPS-induced rabbits, but the effect is brief (T 1/2 is 118-195 s). MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Bradykinin B1 Receptor (B1R)

生化机理

Lys-[Des-Arg9]Bradykinin TFA 是一种天然激肽，是一种强效、高选择性缓激肽 B1 受体激动剂，对人、小鼠和兔子 B1 受体的 K i 分别为 0.12 nM、1.7 nM 和 0.23 nM。 Lys-[Des-Arg9]Bradykinin TFA ha

CAS号

2763588-90-3(DMSO)

分子式

C52H74F3N13O13

分子量

1146.22 g/mol

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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