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Product details

名称

Lys-CoA TFA

别名

赖氨酸辅酶A

英文名称

Lys-CoA TFA

货号

L658820-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存,干燥

运输条件

超低温冰袋运输

产品介绍

Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor ( IC 50 =50-500 nM). Lys-CoA TFA displays >100-fold selectivity for p300 over PCAF (IC 50 =200 μM). Lys-CoA TFA inhibits p300 HAT activity-dependent transcriptional activation. Appearance:Solid IC50& Target:p300 50-500 nM (IC 50 ) In Vitro:Lys-CoA TFA (0.1 and 1 mM; 60 hours) induces a senescent phenotype in human normal melanocytes. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: Normal human melan Biological Activity:Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor ( IC 50 =50-500 nM). Lys-CoA TFA displays >100-fold selectivity for p300 over PCAF (IC 50 =200 μM). Lys-CoA TFA inhibits p300 HAT activity-dependent transcriptional activation.

分子式

C33H54F3N10O21P3S

分子量

1108.82 g/mol

Smiles

OC(C(F)(F)F)=O.O[C@H](C(C)(COP(OP(OC[C@@H]1[C@@H](OP(O)(O)=O)[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O1)(O)=O)(O)=O)C)C(NCCC(NCCSCC(NCCCC[C@H](NC(C)=O)C(N)=O)=O)=O)=O

溶解性

H2O : 70 mg/mL (63.13 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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