L-Buthionine-(S,R)-sulfoximine hydrochloride

L-丁硫氨酸-(S,R)-亚砜亚胺盐酸盐

L-Buthionine-(S,R)-sulfoximine hydrochloride

L661610-1ml

1ml

10mM in DMSO

干燥,-80℃储存

超低温冰袋运输

L-Buthionine-(S,R)-sulfoximine hydrochloride is a cell-permeable, potent, fast acting, orally active and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC 50 value of L-Buthionine-(S,R)-sulfoximine on In Vitro:L-Buthionine-(S,R)-sulfoximine (BSO: 50 μM) treatment for 48 hr results in a 95% decrease in ZAZ and M14 melanoma cell line GSH levels, and a 60% decrease in GST enzyme activity. GST-π protein and mRNA levels are significantly reduced in both cell lines. In Vivo:BSO causes an elevated frequency of DNA deletions during mouse development. BSO treatment reduced GSH concentration in mouse fetuses by 55% and 70% at 2 mM and 20 mM BSO doses, respectively, compared to untreated mice. Co-treatment with 2 mM BSO and 20 mM Biological Activity:L-Buthionine-(S,R)-sulfoximine hydrochloride is a cell-permeable, potent, fast acting, orally active and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC 50 value of L-Buthionine-(S,R)-sulfoximine o

C8H19ClN2O3S

258.77 g/mol

N[C@H](C(O)=O)CCS(CCCC)(=O)=N.[H]Cl