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Product details

名称

LCL521

分子类型

小分子

英文名称

LCL521

货号

L683757-5mg

包装规格

5mg

浓度

≥95%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

LCL521 is an acid ceramidase ( ACDase ) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase ( ASMase ) In Vitro LCL521 (1 µM) acts as a potent inhibitor of cellular ACDase activity, whereas 10 µM LCL521 has an additional, decreased affect on the α-form of this enzyme. LCL521 (10 µM) causes a time-dependent (1 hours and 5 hours) decrease of the α-ACDase form in MCF7 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Oil IC50& Target:ACDase, ASMase

生化机理

LCL521 是一种酸性神经酰胺酶（ACDase）抑制剂。LCL521 还能抑制溶酶体酸性鞘磷脂酶（ASMase）。

CAS号

1226851-11-1

分子式

C31H52N4O7

分子量

592.77 g/mol

PubChem编号

46200045

Isomeric SMILES

CCCCCCCCCCCCCC(=O)N[C@H](COC(=O)CN(C)C)[C@@H](C1=CC=C(C=C1)[N+](=O)[O-])OC(=O)CN(C)C

IIUPAC Name

[(2R,3R)-3-[2-(dimethylamino)acetyl]oxy-3-(4-nitrophenyl)-2-(tetradecanoylamino)propyl] 2-(dimethylamino)acetate

INCHI

1S/C31H52N4O7/c1-6-7-8-9-10-11-12-13-14-15-16-17-28(36)32-27(24-41-29(37)22-33(2)3)31(42-30(38)23-34(4)5)25-18-20-26(21-19-25)35(39)40/h18-21,27,31H,6-17,22-24H2,1-5H3,(H,32,36)/t27-,31-/m1/s1

InChi Key

ANWWJORIPQKJFW-DLFZDVPBSA-N

Smiles

CCCCCCCCCCCCCC(=O)NC(COC(=O)CN(C)C)C(C1=CC=C(C=C1)[N+](=O)[O-])OC(=O)CN(C)C

PubChem CID

46200045

MeSH Entry Terms

(1R, 2R)-2-N-(tetradecanoylamino)-1-(4'-nitrophenyl)-propyl-1,3-O,O-(N,N-dimethylamino)acetate dihydrochloride;LCL521

溶解性

DMSO : 165 mg/mL (278.35 mM; Need ultrasonic) Ethanol : 100 mg/mL (168.70 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

592.384 Da

单同位素质量Monoisotopic Mass

592.384 Da

拓扑极表面积Topological Polar Surface Area

134.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

780.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

7.100

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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