Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) is a potent, selective 5-HT6 receptor antagonist with a K i value of 0.83 nM. Idalopirdine Hydrochloride may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders In Vivo Idalopirdine (intraperitoneal injection, 5 mg/kg, daily, 28 days) Hydrochloride can reduce food intake and body weight in over-eating rat models . Idalopirdine (1 or 2 mg/kg, i.v) Hydrochloride can dose-dependently increase the gamma power during nPO electrical stimulation, enhance effect of donepezil on cortical gamma oscillations but no alteration of sleep-wake patterns in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Wistar rats Dosage: 5 mg/kg Administration: intraperitoneal injection, daily, 28 days Result: Significantly reduced the amount of calories consumed by animals in a palatable diet and significantly reduced plasma levels of glucose, triglycerides and cholesterol. Animal Model: Male Sprague-Dawley ratsDosage: 1 or 2 mg/kg Administration: i.v. Result: No significant increase in the gamma power at 1 mg/kg and significantly increased the gamma power at 2 mg/kg. Significantly enhanced and/or prolonged effect of low-dose donepezil (0.3 mg/kg) on gamma power during 60-minute nPO stimulation after donepezil administration. Form:Solid IC50& Target:5-HT 6 Receptor 0.83 nM (Ki)