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Product details

名称

MG-132,可逆蛋白酶体抑制剂

分子类型

小分子

别名

蛋白酶体抑制剂 | 碳苯并-L-亮氨酰-L-亮氨酰-L-亮氨酸

英文别名

MG132 | Z-LLL-CHO | KBio3_000059 | NCGC00161679-01 | s10322 | SMR002530629 | HMS1989B12 | n-benzyloxycarbonyl-l-leucyl-l-leucyl-l-leucinal | NCGC00161679-03 | NCGC00161679-04 | Z-Leu-leu-leucinal | KBioGR_000030 | {1-[1-(1-Formyl-3-methyl-butylcarbamoyl)-

英文名称

MG-132

货号

M126521-100mg

包装规格

100mg

级别

Moligand™

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

敏感性

对空气、热敏感

产品介绍

MG-132是一种蛋白酶体抑制剂，IC50为100 nM，也抑制钙蛋白酶，IC50为1.2 μM。A proteasome and NF-κB inhibitor. 氨基酸序列：Z-Leu-Leu-Leu-al MG-132 is an inhibitor of proteasome with IC50 of 100 nM, and also inhibits calpain with IC50 of 1.2 μM. A proteasome and NF-κB inhibitor.

生化机理

MG-132 [Z-Leu-Leu-Leu-CHO]是一种蛋白酶体抑制剂，可用于干扰蛋白酶体调控的细胞内蛋白质降解。蛋白酶体处理的这些蛋白质参与了炎症过程和细胞周期调控，因此这类醛类蛋白酶体抑制剂具有广泛的相关性。MG-132 通过阻止 IκB 降解（IC50=3 μM）来抑制 NF-κB 激活（10 μM），从而阻止转录因子为癌细胞提供化疗抗性。它还是一种钙蛋白酶抑制剂。MG-132 [Z-Leu-Leu-Leu-CHO] 是 26S 蛋白酶体的抑制剂，也是 JNK1、c-Jun 和 c-Fos 的激活剂。

CAS号

133407-82-6

分子式

C26H41N3O5

分子量

475.62 g/mol

PubChem编号

462382

Isomeric SMILES

CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1

IIUPAC Name

benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate

INCHI

1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1

InChi Key

TZYWCYJVHRLUCT-VABKMULXSA-N

Smiles

CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1

溶解性

Soluble in DMSO (25 mg/ml), 100% ethanol (25 mg/ml), chloroform:methanol solution (95:5) (10 mg/ml), water (<1 mg/ml), and DMF (~25 mg/ml).

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

475.305 Da

单同位素质量Monoisotopic Mass

475.305 Da

拓扑极表面积Topological Polar Surface Area

114.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

644.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

4.800

Reaxy-Rn

11627647

备注

如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，这些产品最多可以使用一周。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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