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名称

Maleimide PEG aldehyde

别名

马来酰亚胺 PEG 醛

英文别名

Mal-PEG-CHO | CHO-PEG-Mal | ALD-PEG-Mal

英文名称

Maleimide PEG aldehyde

货号

M163885-10mg

包装规格

10mg

浓度

MW 3400 Da

储存温度

避光,-20°C储存

运输条件

超低温冰袋运输

敏感性

对光敏感

产品介绍

Maleimide PEG aldehyde is one of Nanocs premier thiol (-SH) and N-terminal amine group pegylation reagents. Maleimide group reacts with sulfhydryl (thiol) group at pH 6.5-7.5 rapidly and specifically while aldehyde group reacts with the α-amine at the N-terminus produces an intermediate Schiff base. Further reduction with hydride will form a stable C-N bond. Pegylated maleimide and aldehydes are water soluble and all reactions can be carried out in aqueous buffer. Aldehyde reacts with n-terminus amine groups at a pH of from 5.0 to 9.5. Higher pH will result in multiple Pegylation with both terminal and lysine groups.

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