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Product introduction
甲基氯噻嗪是一种苯并噻二嗪。
Chinese name
甲氯噻嗪, 对噻嗪类药物敏感的钠氯共转运抑制剂
English name
6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1lambda6,2,4-benzothiadiazine-7-sulfonamide
Chinese alias
6-氯-3-(氯甲基)-2-甲基-1,1-二氧代-3,4-二氢-1λ6,2,4-苯并噻二嗪-7-磺酰胺
English alias
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide | 6-Chloro-3-chloromethyl-2-methyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide | C07765 | METHYCLOTHIAZIDE COMPONENT OF EUTRON | UNII-R00UU
CAS number
135-07-9
molecular formula
C9H11Cl2N3O4S2
molecular weight
360.2
Exact mass
-
PSA
126
Logp
1.4
Safety
  • Storage conditions: 储存在40°C (104°F)以下,最好在15-30°C (59-86°F)之间,除非制造商另有说明。储存在密闭良好的容器中。
  • Disposal method: SRP:在审查时,土地处理或填埋(卫生填埋)处置实践的标准正在重大修订中。在实施废物残渣(包括废物污泥)的土地处置之前,咨询环境监管机构以获取可接受的处置实践指导。
  • Regulatory information: 新西兰EPA化学品清单状态:2H-1,2,4-苯并噻二嗪-7-磺酰胺,6-氯-3-(氯甲基)-3,4-二氢-2-甲基-,1,1-二氧化物:没有单独批准,但可在适当的团体标准下使用
  • FDA Requirements: 《具有治疗等效性评估的批准药物产品清单》确定了当前上市处方药产品,包括甲基氯噻嗪,这些产品已根据联邦食品、药品和化妆品法案第505节被FDA基于安全性和有效性批准。
  • non-human toxicity value: LD50 小鼠静脉注射 400 毫克/千克
  • Non-human toxic extract: /实验室动物:发育或生殖毒性/在大鼠和兔子中进行的剂量高达4 mg/kg/天的生殖研究表明,由于甲基氯噻嗪对胎儿没有造成伤害的证据。
  • Antidote and first aid: 高级治疗: 对于意识不清、严重肺水肿或呼吸停止的患者,考虑经口或经鼻气管插管进行气道控制。使用带阀面罩装置的正压通气技术可能有益。监测心律并按需治疗心律失常...。用D5W /SRP: "保持通畅",最小流速/开始静脉输液。如有低血容量迹象,使用乳酸盐林格氏液。注意液体过载迹象。考虑肺水肿的药物治疗...。对于有低血容量体征的低血压,谨慎给予液体。注意液体过载迹象...。用地西泮(Valium)治疗癫痫...。使用盐酸丙美卡因辅助眼睛冲洗...。/毒物A和B/
  • Drug Induced Liver Injury: 参考文献:DOI:10.1016/j.drudis.2016.02.015
  • Effects During Pregnancy and Lactation: 截至修订日期,未找到关于甲基氯噻嗪的相关已发表信息。噻嗪类和噻嗪样利尿剂、限制液体摄入和乳房束缚已被用于抑制产后泌乳。利尿剂对这些有效抑制泌乳措施的附加贡献尚未研究。关于利尿剂对已建立的持续泌乳的影响没有数据。
Related
upstream information
Manufacturing method:
氯噻嗪(CID:2720); 一氯乙醛(CID:33)
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Research chemical 1ml

Research chemical 1ml; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 1ml.

item number:M408281-1ml
Product model:1ml
level: 1ml
Lead Time:-
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