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Product introduction

MLi-2 是一种结构新颖、高效、选择性的 LRRK2 激酶抑制剂，具有中枢神经系统活性，IC50为 0.76 nM，有潜力用于帕金森氏病。 MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 (IC50 = 1.4 nM), and a radioligand competition binding assay (IC50 = 3.4 nM).

Specs ⸢ View details ⸥

Chinese name

MLi-2,LRRK2抑制剂, 富亮氨酸重复激酶 2 抑制剂

English name

MLi-2

Chinese alias

(2R,6S)-2,6-二甲基-4-[6-[5-(1-(甲基环丙基)氧基]-1H-吲唑-3-基]嘧啶-4-基]吗啉

English alias

(2R,6S)-2,6-Dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1H-indazol-3-yl]pyrimidin-4-yl]morpholine | cis-2,6-Dimethyl-4-(6-(5-(1-methylcyclopropoxy)-1H-indazol-3-yl)pyrimidin-4-yl)morpholine | rel-3-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-pyrimidinyl]-5-[(

CAS number

1627091-47-7

molecular formula

C21H25N5O2

molecular weight

379.46 g/mol

Exact mass

PSA

76.200 Å²

Logp

3.2

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