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Product introduction

Information MS4078 is an inhibitor and PROTAC (degrader) of ALK . MS4078 reduces the NPM-ALK protein levels in SU-DHL-1 cells and the EML4-ALK protein levels in NCI-H2228 cells with DC50 of 11 nM and 59 nM, respectively. MS4078 induces ALK protein degradation via cereblon and proteasome dependent mechanism and potently inhibits proliferation of SU-DHL-1 cells with IC50 of 33 nM. Targets EML4-ALK (Cell-free assay); NPM-ALK (Cell-free assay) ; 11 nM(DC50)

Specs ⸢ View details ⸥

Chinese name

MS4078

English name

MS4078

Chinese alias

English alias

1-Piperidineacetamide,4-[4-[[5-chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-2-methyl-5-(1-methylethoxy)phenyl]-N-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl

CAS number

2229036-62-6

molecular formula

C45H52ClN9O8S

molecular weight

914.47 g/mol

Exact mass

≥98%

PSA

230.000 Å²

Logp

5.799

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