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Product introduction

Information MLT-748 MLT-748 is a potent, selective and allosteric inhibitor of MALT1 with IC50 of 5 nM, binding at the interface between the caspase and immunoglobulin (Ig3) domains by displacing Trp580 and locking the catalytic site in an inactive state. Targets MALT1 (Cell-free assay) 5 nM In vitro MLT-748 binds MALT1 in the allosteric Trp580 pocket. MLT-748 binds and stabilizes mutant MALT1-W580S. Cleavage of MALT1 substrates is blocked by MLT-748 in B and T cells. MLT-748 rescues MALT1 function in patient MALT1 mut/mut lymphocytes. Cell Research(from reference) Cell lines：Immortalized B cells, human PBMCs, primary human CD3+ T cells, primary CD4+ lymphocytes Concentrations：2 μM Incubation Time：24 h

Specs ⸢ View details ⸥

Chinese name

MLT-748

English name

MLT-748

Chinese alias

English alias

Urea,N-[2-chloro-7-[(1R,2R)-1,2-dimethoxypropyl]pyrazolo[1,5-a]pyrimidin-6-yl]-N'-[5-chloro-6-(2H-1,2,3-triazol-2-yl)-3-pyridinyl]-

CAS number

1832578-30-9

molecular formula

C19H19Cl2N9O3

molecular weight

492.32 g/mol

Exact mass

≥99%

PSA

133.000 Å²

Logp

1.700

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