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Product introduction

产品介绍： UNC2025 是一种强效、ATP 竞争性的，具有口服活性的 Mer/Flt3 抑制剂，IC50 值分别为 0.74 nM 和 0.8 nM。UNC2025 对MERTK 的选择性是 Axl 的 45 倍 (IC50=122 nM; Ki=13.3 nM)。UNC2025 具有良好的 PK 特性，可用于急性白血病的研究。 Product description： UNC2025 is a potent, ATP-competitive and highly orally active Mer/Flt3 inhibitor with IC50 values of 0.74 nM and 0.8 nM, respectively. UNC2025 is >45-fold selectivity for MERTK relative to Axl (IC50= 122 nM; Ki = 13.3 nM). UNC2025 exhibits an excellent PK properties, and can be used for the investigation of acute leukemia.

Specs ⸢ View details ⸥

Chinese name

mrx-6313

English name

mrx-6313

Chinese alias

English alias

CAS number

1429881-91-3

molecular formula

C28H40N6O

molecular weight

476.66 g/mol

Exact mass

10mM in DMSO

PSA

69.500 Å²

Logp

4.000

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