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Product introduction

Marimastat (BB-2516, TA2516)是一种广谱的 matrix metalloprotease (MMP) 抑制剂，对 MMP-9，MMP-1，MMP-2，MMP-14 和 MMP-7 的 IC50 分别为 3 nM，5 nM，6 nM，9 nM 和 13 nM。Phase 3。产品应用： Marimastat已用作下列抑制剂：金属蛋白酶2/9 (MMP2/9)，以研究其对小鼠运动介导的白细胞介素-6 (IL-6)释放的影响；金属蛋白酶，测定铜绿假单胞菌培养物中的蛋白酶活性；金属蛋白酶10 (MMP10)，研究其对结合MMP10的单克隆抗体H3的影响

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Chinese name

Marimastat (BB-2516), 基质金属蛋白酶 7 抑制剂

English name

Marimastat (BB-2516)

Chinese alias

马立马司他 (BB-2516)

English alias

Butanediamide, N4-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)-, (2S,3R)- | GI 5712 | Q6763659 | (2S,3R)-3-[[(1S)-2,2-Dimethyl-1-(methylcarbamoyl)propyl]carbamoyl]-2-hydroxy-5-methylhexanohydroxamic acid | (2S,3R)-

CAS number

154039-60-8

molecular formula

C15H29N3O5

molecular weight

331.41 g/mol

Exact mass

PSA

128.000 Å²

Logp

0.5

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