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Product introduction

metamizole 是一种吡唑，是在 C-4 位被甲基(磺甲基)氨基取代的非吡啶，其钠盐 metamizole 钠曾广泛用作强效镇痛药和退热药，但由于可能引起粒细胞缺乏症的风险，自 1970 年代起已从许多市场撤回。它具有非麻醉性镇痛药、退热药、抗风湿药、周围神经系统药物、前体药物、抗炎药和环氧化酶 3 抑制剂的作用。它是吡唑和氨基磺酸的成员。它与非吡啶功能相关。它是 metamizole(1-) 的共轭酸(1)。

Specs ⸢ View details ⸥

Chinese name

metamizole

English name

[(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-methylamino]methanesulfonic acid

Chinese alias

安乃近

English alias

CAS number

50567-35-6

molecular formula

C13H17N3O4S

molecular weight

311.36

Exact mass

PSA

89.5

Logp

0.000

Safety

Hepatotoxicity：可能性评分：A（虽有描述但罕见引起明显肝损伤的病例）。

Drug Induced Liver Injury：参考文献：DOI:10.1016/j.drudis.2019.09.022

Effects During Pregnancy and Lactation：截至修订日期，未找到相关已发表信息。

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